New generation of Fully Human Monoclonal Antibody Library: MG-Umab library
MilleGen has genetically engineered human recombinant antibody libraries with high complexity (Mondon et al, Biotechnology J. 2007, 2:76-82. PMID: 17225253 and patent WO2007137616).
In addition, a proofreading process has enriched the library with open reading frame (ORF) antibody sequences and improved the library quality selecting soluble antibodies. This new generation of library of several billion clones is one of thebest optimized quality library on the market with 94 % of clones encoding full-length antibodies. The high rate of functional antibodies allows a rapid and successful screening in order to provide an even wider range of promising antibody drug candidates per target.
To complete the preclinical and clinical developments of your antibodies, we are proposing to select anti-idiotypic antibodies from our antibody library. Anti-idiotype antibodies (anti-Id) are antibodies against the antigen binding site of another antibody. Anti-idiotypic antibody isolations using in vitro selection of antibody library have been proved to be a very effective process compared to mouse immunisation. Anti-idiotypic antibodies are ideal for preclinical and clinical development (in pharmacokinetic (PK) and pharmacodynamic studies) of human antibody drugs.
