New generation of Fully Human Monoclonal Antibody Library
MilleGen has genetically engineered human recombinant antibody libraries with high complexity (Mondon et al, Biotechnology J. 2007, 2:76-82. PMID: 17225253 and patent WO2007137616).
In addition, a proofreading process has enriched the library with open reading frame (ORF) antibody sequences and improved the library quality selecting soluble antibodies. This new generation of library of 3.4 billion clones is the highest quality library on the market with 94 % of clones encoding full-length and functional antibodies. The high rate of functional antibodies allow a rapid and successful screening in order to provide an even wider range of promising antibody drug candidates per target.
Optimal quality of the library
Functional antibody fragments previously enriched to be efficiently expressed in the screening process
Germline diversity holds the generally selected functional germline genes
Protein screening: up to 80% of positive selected clones
Peptide screening: up to 70% of positive clones
This quality optimized library is proposed to customers as a service/contracted work. This service/contracted work includes selecting fully human antibody candidates and their optimisation by directed molecular evolution (MutaGen™). The high potent products will be expressed in the format of a whole human antibody molecule ready to enter into clinical development.
